Popescu, Laura Madalina and Piticescu, Roxana Mioara and Rusti, Cristina Florentina and Maly, Marek and Danani, Andrea and Kintzios, Spiros and Grinan, Maria Teresa Valero (2011) Preparation and characterization of new hybrid nanostructured thin films for biosensors design. Materials Letters, 65 (13). pp. 2032-2035. ISSN 0167-577X
Full text not available from this repository.Abstract
The present paper reports on an innovative route for the preparation of new hybrid nanostructured thin films based on hydroxyapatite and functionalized polyurethane. Hybrid nanopowders based on hydroxyapatite and functionalized polyurethane have been synthesized by a hydrothermal method with high pressure and low temperature conditions and further used for spin coating deposition. Biocompatible thin films with a thickness of about 50 nm have been deposited onto Si/SiO2/Ti/Au substrates and their properties recommend them suitable as possible electrodes for the fabrication of impedance biosensors. Hybrid materials with improved properties are obtained, combining the mechanical properties of polyurethane with biocompatible properties of hydroxyapatite (bioactivity and osteoconductivity). The presence of functional groups in polyurethane structure ensures the existence of strong interactions between components and an increased affinity of the thin films for further protein bonding in biosensor design. Hybrid nanostructured thin films based on hydrothermally synthesized hydroxyapatite–polyurethane nanopowders could enhance the amount of immobilized biomolecules in the construction of an impedance biosensor for diagnosis and therapy of bone diseases.
| Item Type: | Scientific journal article, Newspaper article or Magazine article |
|---|---|
| Subjects: | Physical sciences > Materials science |
| Department/unit: | Dipartimento tecnologie innovative > Istituto di ingegneria meccanica e tecnologia dei materiali |
| Depositing User: | Andrea Danani |
| Date Deposited: | 06 Mar 2015 06:36 |
| Last Modified: | 08 Jul 2016 10:00 |
| URI: | http://repository.supsi.ch/id/eprint/6231 |
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