Kalt, Matthias and Ros, Angela and Iamartino, Piero and Mercuri, Salvatore and Crivelli, Daniele and Joost, Berndt (2018) Mechano-Chemical Activation and Stabilization of APIs by co-Milling. In: PBP World Meeting, 19.03.2018 - 22.03.2018, Granada, Spain.
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Abstract
Poor drug dissolution and solubility are often the cause for low bioavailability. Counteracting can include physical modifications of active ingredients by increasing the surface area, solubility and wettability of powder particles with focus on particle size reduction and specific surface area increase or - on the other hand – with focus on the generation of the amorphous state [2]. During milling both the size reduction as well as the induced transition of a crystalline to an amorphous compound can be conducted at the same time. The aim of this work is to study the influence of general milling parameters like stressing energy (SE) and stressing number (SN) on particle size reduction and mechano-chemical activation (MCA) by vibration milling using a small scale mill. As feed particles lactose monohydrate, itraconazole (ITZ), a BSC II class antifungal drug and a blend of itraconazole and HPMC (1:3) were used.
Item Type: | Article in conference proceedings or Presentation at a conference (Poster) |
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Subjects: | Engineering Engineering > Chemical, process & energy engineering |
Department/unit: | Dipartimento tecnologie innovative > Istituto di ingegneria meccanica e tecnologia dei materiali |
Depositing User: | Daniele Crivelli |
Date Deposited: | 03 Apr 2018 05:56 |
Last Modified: | 03 Apr 2018 05:56 |
URI: | http://repository.supsi.ch/id/eprint/9449 |
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