Hameau, Séverine and Fruchon, Séverine and Bijani, Christian and Barducci, Alessandro and Blanzat, Muriel and Poupot, Rémy and Pavan, Giovanni Maria and Caminade, Anne-Marie and Turrin, Cédric-Olivier (2015) Theoretical and experimental characterization of amino-PEG-phosphonate-terminated Polyphosphorhydrazone dendrimers: Influence of size and PEG capping on cytotoxicity profiles. Journal of Polymer Science Part A: Polymer Chemistry, 53 (6). pp. 761-774. ISSN 1099-0488
Full text not available from this repository.Abstract
The synthesis of new series of PPH (poly(phosphorhydrazone)) dendrimers with amino-PEG phosphonates or the corresponding amino-PEG phosphonic acids as terminal groups is presented, from generations 1–3. The size of PEG-terminated dendrimers is experimentally measured by diffusional NMR, and by means of dynamic light scattering. Classical molecular dynamics and well-tempered metadynamics simulations are used to assess or confirm the formation of aggregates in some cases. The influence of PEG capping on the cytotoxicity profiles of the dendrimers is evaluated on human peripheral blood mononuclear cells by means of LIVE/DEAD assays, and confirms the importance of PEG capping to ensure low cytotoxicity.
| Item Type: | Scientific journal article, Newspaper article or Magazine article |
|---|---|
| Subjects: | Physical sciences > Chemistry |
| Depositing User: | Giovanni Maria Pavan |
| Date Deposited: | 23 Aug 2016 05:47 |
| Last Modified: | 23 Aug 2016 05:47 |
| URI: | http://repository.supsi.ch/id/eprint/7655 |
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