Albertazzi, Lorenzo and Mickler, Frauke M and Pavan, Giovanni Maria and Salomone, Fabrizio and Bardi, Giuseppe and Panniello, Mariangela and Amir, Elizabeth and Kang, Taegon and Killops, Kato L and Bräuchle, Christoph and Amir, Roey J and Hawker, Craig J (2012) Enhanced bioactivity of internally functionalized cationic dendrimers with PEG cores. Biomacromolecules, 13 (12). pp. 4089-4097. ISSN 1525-7797
Full text not available from this repository.Abstract
Hybrid dendritic-linear block copolymers based on a 4-arm poly(ethylene glycol) (PEG) core were synthesized using an accelerated AB2/CD2 dendritic growth approach through orthogonal amine/epoxy and thiol-yne chemistries. The biological activity of these 4-arm and the corresponding 2-arm hybrid dendrimers revealed an enhanced, dendritic effect with an exponential increase in cell internalization concomitant with increasing amine end groups and low cytotoxicity. Furthermore, the ability of these hybrid dendrimers to induce endosomal escape combined with their facile and efficient synthesis makes them attractive platforms for gene transfection. The 4-arm-based dendrimer showed significantly improved DNA binding and gene transfection capabilities in comparison with the 2-arm derivative. These results combined with the MD simulation indicate a significant effect of both the topology of the PEG core and the multivalency of these hybrid macromolecules on their DNA binding and delivery capablities.
| Item Type: | Scientific journal article, Newspaper article or Magazine article |
|---|---|
| Subjects: | Physical sciences > Chemistry |
| Depositing User: | Giovanni Maria Pavan |
| Date Deposited: | 23 Aug 2016 07:11 |
| Last Modified: | 23 Aug 2016 07:11 |
| URI: | http://repository.supsi.ch/id/eprint/7625 |
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