McAuliffe, John C and Wang, Wei-Lein and Pavan, Giovanni Maria and Pricl, Sabrina and Yang, Dan and Chen, Su S and Lazar, Alexander JF and Pollock, Raphael E and Trent, Jonathan C (2008) Unlucky number 13? Differential effects of KIT exon 13 mutation in gastrointestinal stromal tumors. Molecular oncology, 2 (2). pp. 161-163. ISSN 1574-7891
Full text not available from this repository.Abstract
Gastrointestinal stromal tumor (GIST) represents the majority of soft tissue sarcomas arising from the GI tract. Most GISTs encode activating mutations in the kit gene, an important genetic event in tumorigenesis. Imatinib mesylate (imatinib, Gleevec™; Novartis, Basel, Switzerland) has revolutionized the management of patients with advanced disease by targeting the aberrant kinase activity of Kit.
| Item Type: | Scientific journal article, Newspaper article or Magazine article |
|---|---|
| Subjects: | Physical sciences > Chemistry > Medicinal chemistry > Pharmaceutical chemistry |
| Depositing User: | Giovanni Maria Pavan |
| Date Deposited: | 23 Aug 2016 07:22 |
| Last Modified: | 23 Aug 2016 07:22 |
| URI: | http://repository.supsi.ch/id/eprint/7618 |
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