Milani, Alessandra and De Pas, Tommaso and Noberasco, Cristina and McDonnel, Colette and Libutti, Livio and Limardi, Ivan and Zencovich, Claudia and Boselli, Sabrina and Bianchi, Monica and de Braud, Filippo (2007) A 15-min premedication for 1-h paclitaxel infusion: Optimizing patients’ care. Lung Cancer, 58 (2). pp. 300-301. ISSN 0169-5002
Full text not available from this repository.Abstract
Paclitaxel is a plant product highly active in numerous cancers, but anaphylactic-like hypersensitivity reactions with it have been reported in about 28% of patients receiving the drug. Thirty to sixty minutes are needed to give a standard premedication with steroids and diphenhydramine, leading to patients and nurses' discomfort and stealing time from other infusional treatments. Eighty-nine patients with advanced NSCLC never pre-treated with taxanes, received paclitaxel followed by gemcitabine on days 1, 8, 15 q4wks. Premedication consisted of prednisone 25 mg/os on day 0 and hydrocortisone plus clorfenamina maleato given intravenous on day 1 by a 15 min infusion immediately before paclitaxel administration. Hypersensitivity reactions occurred in 3/341 (0.8%) cycles. In all three cases we observed severe dyspnoea and bronchospasm, that required treatment discontinuation but one was probably due to gemcitabine and another had a protracting time after premedication. A 15-min premedication infusion administered immediately before paclitaxel appeared to be highly effective in patients treated with 1h-infusion paclitaxel.
| Item Type: | Scientific journal article, Newspaper article or Magazine article |
|---|---|
| Subjects: | Medicine and Dentistry > Clinical medicine |
| Department/unit: | Dipartimento economia aziendale, sanità e sociale > Centro competenze pratiche e politiche sanitarie |
| Depositing User: | Monica Bianchi |
| Date Deposited: | 12 Mar 2015 06:23 |
| Last Modified: | 17 Oct 2023 10:00 |
| URI: | http://repository.supsi.ch/id/eprint/6280 |
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