Generation-Dependent Molecular Recognition Controls Self-Assembly in Supramolecular Dendron- Virus Complexes

Doni, Giovanni and Kostiainen, Mauri A and Danani, Andrea and Pavan, Giovanni Maria (2010) Generation-Dependent Molecular Recognition Controls Self-Assembly in Supramolecular Dendron- Virus Complexes. Nano letters, 11 (2). pp. 723-728. ISSN 1530-6984

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Abstract

In this work molecular dynamics simulation identifies a clear link between the dendron−virus multivalent molecular recognition and the nature of the consequent self-assembly. Data demonstrate how a weak hydrophobic association is transformed in an electrostatic self-assembly, orders of magnitude stronger, depending on the dendron generation used to assemble the viruses. This opens a new frontier in the engineering of hierarchical self-assemblies, potentially enabling the control of the supramolecular properties by acting at the single-molecule level.

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