“Emptying of the diclofenac stratum corneum reservoir is influenced by the type of application”

Clijsen, Ron and Baeyens, Jean Pierre and Barel, André Odilon and Clarys, Peter (2012) “Emptying of the diclofenac stratum corneum reservoir is influenced by the type of application”. In: World Congress of the International Society for Biophysics and Imaging of the Skin (ISBS), 28-30 November 2012 , Copenhagen, Denmark.

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R. Clijsen 1,2,3, J.P. Baeyens 1,2, A.O. Barel 1, P. Clarys 1 1 Faculty of Physical Education and Physiotherapy, Vrije Universiteit Brussel, Brussels, BELGIUM 2 Department of Health Sciences, University of Applied Sciences and Arts of Southern Switzerland, Landquart, SWITZERLAND 3 University College Physiotherapy, Thim van der Laan AG, Landquart, SWITZERLAND Introduction: The information concerning the efficacy and the penetration profiles of substances used in the physiotherapy setting is scarce. The aim of our study was to estimate the emptying of the diclofenac SC reservoir after respectively a passive, occlusive and electrically assisted application of diclofenac (DF). Methods: In total 5 different groups, of healthy volunteers (n= 60, 24 male and 37 female), participated in this study. A 1% DF (Voltaren Emulgel®, Novartis) formulation (12mg) was applied on the volar forearms on randomized defined circular skin areas of 7cm2. DF was applied for 20 minutes under 3 different conditions at the same time; passive diffusion under a semi occlusive sponge, an application without occlusion and an iontophoretic application. To estimate the bioavailability of DF in the skin, methyl nicotinate (MN) responses (Minolta Chromameter a* parameter) at the different moments post initial DF application (respectively 1.5, 6, 24, 32, 48, 72, 96, 120 hours) were compared (ANOVA procedure with Bonferroni corrected post-hoc tests). Significant level was set at 5%. Results: At 1.5 hours after the initial DF application a significant decreased response was detected for the occluded and iontophorectically delivery. After 48 hours the iontophoretic DF delivery was no longer significantly reduced (p=0.296). At 72 hours post DF application only the response after the passively delivered DF remained significant (p=0.038). After 96 respectively 120 hours no difference between the MN responses was detected. Conclusion: The formation and emptying of a DF SC reservoir is influenced by the DF application mode.

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