Factors Associated With COVID-19 Non-Vaccination in Switzerland: A Nationwide Study

Sabatini, Serena and Kaufmann, Marco and Fadda, Marta and Tancredi, Stefano and Noor, Nazihah and Van Der Linden, Bernadette and Cullati, Stéphane and Frank, Irene and Michel, Gisela and Harju, Erika and Luedi, Chantal and Frei, Anja and Ballouz, Tala and Menges, Dominik and Fehr, Jan and Kohler, Philippe and Kahlert, Christian R. and Scheu, Victor and Ortega, Natalia and Chocano-Bedoya, Patricia O. and Rodondi, Nicolas and Stringhini, Silvia and Baysson, Hélène and Lorthe, Elsa and Caiata Zufferey, Maria and Suggs, Suzanne and Albanese, Emiliano and Vincentini, Julia and Bochud, Murielle and D'Acremont, Valérie and Gonseth Nusslé, Semira and Imboden, Medea and Keidel, Dirk and Witzig, Melissa and Probst-Hensch, Nicole and von Wyl, Viktor (2023) Factors Associated With COVID-19 Non-Vaccination in Switzerland: A Nationwide Study. International Journal of Public Health, 68.

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Objectives: We compared socio-demographic characteristics, health-related variables, vaccination-related beliefs and attitudes, vaccination acceptance, and personality traits of individuals who vaccinated against COVID-19 and who did not vaccinate by December 2021. Methods: This cross-sectional study used data of 10,642 adult participants from the Corona Immunitas eCohort, an age-stratified random sample of the population of several cantons in Switzerland. We used multivariable logistic regression models to explore associations of vaccination status with socio-demographic, health, and behavioral factors. Results: Non-vaccinated individuals represented 12.4% of the sample. Compared to vaccinated individuals, non-vaccinated individuals were more likely to be younger, healthier, employed, have lower income, not worried about their health, have previously tested positive for SARS-CoV-2 infection, express lower vaccination acceptance, and/or report higher conscientiousness. Among non-vaccinated individuals, 19.9% and 21.3% had low confidence in the safety and effectiveness of SARS-CoV-2 vaccine, respectively. However, 29.1% and 26.7% of individuals with concerns about vaccine effectiveness and side effects at baseline, respectively vaccinated during the study period. Conclusion: In addition to known socio-demographic and health-related factors, non- vaccination was associated with concerns regarding vaccine safety and effectiveness.

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