Sabia, Carmine and Casalini, Tommaso and Cornolti, Luca and Spaggiari, Marco and Frigerio, Giovanni and Martinoli, Luca and Martinoli, Alberto and Buffo, Antonio and Marchisio, Daniele L and Barbato, Maurizio C (2022) A novel uncoupled quasi-3D Euler-Euler model to study the spiral jet mill micronization of pharmaceutical substances at process scale: Model development and validation. Powder Technology. p. 117573.
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Abstract
In this work we present a novel approach to model the micronization of pharmaceutical ingredients at process scales andtimes. 3D single-phase fluid-dynamics simulations are used to compute the gas velocity field within a spiral jet mill which are provided as input in a 1D compartmentalized model to calculate solid velocities along the radial direction. The particles size reduction is taken into account through a breakage kernel that is function of gas energy and local solid holdup. Simulation results are validated against micronization experiments for lactose and paracetamol, comparing the model predictions with D10, D50 and D90 diameters values coming from Design of Experiments isosurfaces. The developed model allows for a fair estimation of the outlet particle size distribution in a short computational time, with very good predictions especially for D90 values.
| Item Type: | Scientific journal article, Newspaper article or Magazine article |
|---|---|
| Subjects: | Engineering |
| Department/unit: | Dipartimento tecnologie innovative > Istituto di ingegneria meccanica e tecnologia dei materiali |
| Depositing User: | Carmine Sabia |
| Date Deposited: | 09 Jun 2022 08:48 |
| Last Modified: | 09 Jun 2022 08:48 |
| URI: | http://repository.supsi.ch/id/eprint/13443 |
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