Psychological determinants of target organ damage in hypertensive patients: focus on Pulse Wave Velocity and depression

Greco, A. and Maloberti, A. and Varrenti, M. and Bassi, I. and Piccinelli, E. and Panzera, F. and Laurent, S. and Boutouyrie, P. and D'Addario, M. and Annoni, Anna Maria and Steca, P. and Giannattasio, C. (2017) Psychological determinants of target organ damage in hypertensive patients: focus on Pulse Wave Velocity and depression. In: Association for Research into Arterial Structure and Physiology, 12-14 October 2017, Pisa, Italy. (Unpublished)

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Objective: Prior studies have suggested that the principal determinants of arterial stiffening are age, Blood Pressure (BP) and others CV risk factors such as dyslipidemia and diabetes, and that - that arterial stiffness was associated with depression in the elderly and in healthy adolescents, but no study has focused on the role of depression and other psychological variables in hypertensive patients. The aim of the current cross-sectional study was to evaluate the association between depression, anxiety, perceived stress, Type A and Type D personality, and Pulse Wave Velocity (PWV) in a cohort of hypertensive patients. Methods: a total of 259 outpatients (ages 18-80 years) affected by essential hypertension were recruited; aortic stiffness was evaluated by PWV. Moreover, anamnestic data, clinical BP, and laboratory data were evaluated and patients were asked to complete a battery of psychological questionnaires. The associations between psychological variables and PWV was explored using multivariate stepwise linear regression analysis. Results: the mean age was 55.9±10.1years, SBP and DBP were 135.6±17.7 and 82.5±9.1mmHg and PWV was 8.6±2.1m/s. The results showed that age (beta=0.284, p<0.001), pulse pressure (beta=0.369, p<0.001), dyslipidemia (beta=0.130, p=0.012), family history of CV disease (beta=-0.123, p=0.017), and depression (beta=0.126, P=0.014) were significantly and independently associated with PWV. Conclusions: the current study shows that higher levels of depression is related to higher PWV, while anxiety, perceived stress, Type A personality, and Type D personality are not associated with arterial stiffness. Depression assessment and target intervention to reduce it are recommended in hypertensive patients.

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