Psychological determinants of target organ damage in hypertensive patients: focus on type A Personality and Left Ventricular Mass Index

Greco, A. and Maloberti, A. and Sormani, P. and Colombo, G. and Giupponi, L. and Laurent, S. and Boutouyrie, P. and D'Addario, M. and Annoni, Anna Maria and Moreo, A. and Giannattasio, C. and Steca, P. (2017) Psychological determinants of target organ damage in hypertensive patients: focus on type A Personality and Left Ventricular Mass Index. In: Association for Research into Arterial Structure and Physiology, 12-14 October 2017, Pisa, Italy. (Unpublished)

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Abstract

Background: increased Left Ventricular Mass Index (LVMI) is a well known risk factor for cardiac morbidity and mortality; clinical evolution and progression of established CV diseases are related to a range of psychological characteristics. Little is known about LVMI and its association with psychological characteristics in arterial Hypertension (HT) patients. The aim of the current cross-sectional study was to evaluate the association between Type A and Type D personality, depression, anxiety, perceived stress, and LVMI in a cohort of hypertensive patients. Methods: a total of 244 outpatients (ages 18-80 years) affected by essential hypertension were recruited. Anamnestic data, clinical BP, laboratory data, and LVMI were evaluated. Patients were asked to complete a battery of psychological questionnaires. The associations between psychological variables and LVMI was explored using multivariate stepwise linear regression analysis. Results: the mean age was 55.9±10.1years, SBP and DBP were 135.6±17.7 and 82.5±9.1mmHg. Factors associated with LVMI in univariate analysis were age, sex, mean blood pressure, pulse pressure, presence of diabetes. The multivariate stepwise linear regression analysis showed that sex (beta=0.252, p<0.001), age (beta=0.135, p<0.037), mean blood pressure (beta=0.178, p=0.003), family history of CV disease (beta=0.129, p=0.027), and Type A personality (beta=0.148, P=0.014) were significantly and independently associated with LVMI. These associations were independent of blood pressure components. Conclusion: among psychological factors, higher levels of Type A personality are related to higher LVMI only. This study seems to suggest that Type A personality play a role in the presence of hypertension

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