Bedtime to morning variation of mobility after nocturnal sleep in Parkinson's disease

Ratti, P and Faraci, Francesca Dalia and Hackethal, S and Pereno, M and Ferlito, C and Mascheroni, Alessandro and Caverzasio, S and Bonoli, S and Guglielmetti, L and Amato, N and Puiatti, Alessandro and Kaelin-Lang, A (2017) Bedtime to morning variation of mobility after nocturnal sleep in Parkinson's disease. UNSPECIFIED. Sleep Medicine, 40. e276.

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Abstract

Up to 50% of the patients with Parkinson´s disease experience a transient but clinically relevant improvement in mobility on morning awakening, even before taking their habitual antiparkinsonian medications. This phenomenon has been described as "Sleep Benefit” (SB). We aimed to evaluate the effect of nocturnal sleep on mobility on morning awakening, compared to the effect of habitual morning dopaminergic medications. Moreover, we explored if this effect varied differently among patients experiencing or not SB and if it was influenced by overall quality of nocturnal sleep macrostructure.

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