An experimental method to measure APIs residence time distribution in the jet mill micronization process

Bottin, Matteo and Iamartino, Piero and Crivelli, Daniele and Joost, Berndt (2018) An experimental method to measure APIs residence time distribution in the jet mill micronization process. In: PBP - World Meeting, 19.03.2018 - 22.03.2018, Granada, Spain.

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Abstract

Micronization by jet mill technology is a method of improving the bioavailability of poorly soluble APIs (Active Pharmaceutical Ingredient). The particle’s residence time distribution (RTD) is a key factor on which the number of particle impacts depends, hence, the achievable particle size reduction and the amorphization state, the so called mechano-chemical activation (MCA). To date, just a few attempts have been made to quantify the particles RTD in jet mill micronization processes, the most relevant are: • Direct measurement by radioactive tracers, method developed by Müller F. et al. [1] in 1996; • Indirect measurement by means of RT’s particle size dependence with probability functions, study performed by Gommeren H.J.C. et al. [2] in 1996. The state of the art of the existent methods present some limitations, the first because of technological complexity, the second being inaccurate (based on probability functions and assumptions). This work deals with the development and testing of a robust, safe and affordable experimental measuring technique suitable to quantify the particles mean residence time (MRT) in micronization processes. The developed method, based on phosphorescent tracer particles emitting green afterglow light, is a partial adaptation of the method developed by Harris et al. [3]. The application of the measurement system is thought for spiral jet mills, however it is applicable to any other solid-gas multi-phase flow process.

Item Type:	Article in conference proceedings or Presentation at a conference (Poster)
Subjects:	Engineering > Mechanical engineering
Department/unit:	Dipartimento tecnologie innovative > Istituto di ingegneria meccanica e tecnologia dei materiali
Depositing User:	Daniele Crivelli
Date Deposited:	03 Apr 2018 05:56
Last Modified:	03 Apr 2018 05:56
URI:	http://repository.supsi.ch/id/eprint/9450

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