Clijsen, Ron and Baeyens, Jean Pierre and Barel, André Odilon and Clarys, Peter (2013) Influence of the timing of ultrasound application on the penetration of corticosteroids. Skin Research and Technology, 19 (1). e279-e282.
Full text not available from this repository.Abstract
Background: The application of ultrasound to enhance the transdermal transport of drugs is often referred to as ‘sonophoresis’. In physiotherapy sonophoresis is applied to the skin through two different procedures: (1) the pre-treatment procedure where the skin is treated with ultrasound irradiation prior to the drug application and (2) a simultaneous treatment mode, where the skin is treated with ultrasound during the application of the pharmacologic substance. The aim of this study was to compare the bioavailability of halcinonide in the stratum corneum comparing the ultrasound pre-treatment vs. the simultaneous treatment method. Methods: The effect of pre and simultaneous ultrasound treatment (1 MHz, 1 W/cm2) was evaluated on the halcinonide blanching response using tristimulus colorimetry 2 h after the initial application. Results: Within the evaluation period, only the ultrasound pretreatment method resulted in a significant blanching response. Conclusion: Timing of the ultrasound application seems to influence the availability and percutaneous penetration process and should be taken into account when estimating the ultrasound enhancing effect. Key words: ultrasound – sonophoresis – halcinonide – corticosteroids – simultaneous treatment – pre-treatment – skin blanching assay – tristimulus colorimetry
Item Type: | Scientific journal article, Newspaper article or Magazine article |
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Uncontrolled Keywords: | ultrasound;sonophoresis;halcinonide;corticosteroids;simultaneous treatment;pre-treatment;skin blanching assay;tristimulus colorimetry |
Subjects: | Subjects Allied to Medicine > Anatomy, physiology & pathology > Physiotherapy |
Department/unit: | Dipartimento economia aziendale, sanità e sociale > Laboratorio di ricerca in riabilitazione |
Depositing User: | Ron Clijsen |
Date Deposited: | 28 Mar 2013 11:08 |
Last Modified: | 14 May 2021 11:00 |
URI: | http://repository.supsi.ch/id/eprint/2263 |
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