Jiang, Miao and Corna, Laurie and Amati, Rebecca and Piumatti, Giovanni and Franscella, Giovanni and Crivelli, Luca and Albanese, Emiliano (2023) Prevalence and association of frailty with SARS-CoV-2 infection in older adults in Southern Switzerland—Findings from the Corona Immunitas Ticino Study. BMC Geriatrics, 23 (1). ISSN 1471-2318
Full text not available from this repository.Abstract
Background Frailty is an age-associated state of increased vulnerability to stressors that strongly predicts poor health outcomes. Epidemiological evidence on frailty is limited during the COVID-19 pandemic, and whether frailty is associated with the risk of infection is unknown. Objectives We derived a robust Frailty Index (FI) to measure the prevalence of frailty and its risk factors in community-dwelling older adults in Southern Switzerland (Ticino), and we explored the association between frailty and serologically confirmed SARS-CoV-2 infection. Methods In September 2020, we recruited a random sample of community-dwelling older adults (65 +) in the Corona Immunitas Ticino prospective cohort study (CIT) and assessed a variety of lifestyle and health characteristics. We selected 30 health-related variables, computed the Rockwood FI, and applied standard thresholds for robust (FI < 0.1), pre-frail (0.1 ≤ FI < 0.21), and frail (FI ≥ 0.21). Results Complete data for the FI was available for 660 older adults. The FI score ranged between zero (no frailty) and 0.59. The prevalence of frailty and pre-frailty were 10.3% and 48.2% respectively. The log-transformed FI score increased by age similarly in males and females, on average by 2.8% (p < 0.001) per one-year increase in age. Out of 481 participants with a valid serological test, 11.2% were seropositive to either anti-SARS-CoV-2 IgA or IgG. The frailty status and seropositivity were not statistically associated (p = 0.236). Conclusion Advanced age increases the risk of frailty. The risk of COVID-19 infection in older adults may not differ by frailty status. Keywords Frailty, Epidemiology, Older adults, COVID-19
| Item Type: | Scientific journal article, Newspaper article or Magazine article |
|---|---|
| Subjects: | Social studies Social studies > Sociology |
| Department/unit: | Dipartimento economia aziendale, sanità e sociale > Centro competenze anziani |
| Depositing User: | Roberta Torriani |
| Date Deposited: | 09 Feb 2023 05:32 |
| Last Modified: | 09 Feb 2023 05:37 |
| URI: | http://repository.supsi.ch/id/eprint/13783 |
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