Pacifico, Deborah and Mele, Federico and Annoni, Anna Maria and Fiordelli, Maddalena and Jovic, Sandra and Giacchetto-Sasselli, Isabella and Piccoli, L. and Corna, Laurie and Di Stefano, Roberto and Pertoldi, Wiliam and Sallustro, Federica and Albanese, Emiliano (2022) COVID-19 infections and cognitive function in long-term care home residents in Southern Switzerland – empirical evidence of ‘cognitive COVID’. In: 35th Global Conference of Alzheimer’s Disease International, 10.06.2022, London, GB - Webinar. (Unpublished)
Full text not available from this repository.Abstract
AIM: SARS-CoV-2, the virus that causes COVID-19, is neurotropic and may have a direct impact on cognition. We aimed to explore the association of SARS-CoV-2 seropositivity with cognitive function in a sample of older adults living in long-term care (LTC) homes. METHODS: We conducted a structured cognitive assessment in the context of a longitudinal study on COVID-19 seroprevalence among LCT residents in Southern Switzerland. Measurement of SARS-Cov-2 RBD IgG, IgM and IgA antibodies was performed with enzyme-linked immunosorbent assays (ELISAs) developed by Humabs Biomed. Trained interviewers assessed cognitive function using the validated REDcap electronic version of the 10/66 schedule, which includes the CSI “D”, the CERAD animal verbal fluency and ten-word list learning tasks. RESULTS: The sample included 162 participants aged 66 to 102 years (mean age=87.6 years; SD=6.4; 82.7% female). 47.5% of the sample resulted positive to a serological test performed between mid-November2020 and mid-January 2021 (COVID-19 wave 2). In age- and education-adjusted linear regression models, global cognitive function scores were lower in residents with a positive serological test compared to those who tested negative (β=-0.17; p<0.05). We found similar results for the memory subdomain (β=-0.18; p<0.05), but not for language, verbal fluency, and orientation (all p values >0.05). CONCLUSION: COVID-19 seropositivity was cross-sectionally associated with lower cognitive performance in older adults living in LCT homes relative to those who tested negative. Further investigations are warranted to study the potential long-term impact of COVID-19 on cognitive function and decline.
| Item Type: | Article in conference proceedings or Presentation at a conference (Lecture) |
|---|---|
| Subjects: | Social studies Social studies > Sociology |
| Department/unit: | Dipartimento economia aziendale, sanità e sociale > Centro competenze anziani |
| Depositing User: | Roberta Torriani |
| Date Deposited: | 28 Jun 2022 07:42 |
| Last Modified: | 28 Jun 2022 07:49 |
| URI: | http://repository.supsi.ch/id/eprint/13290 |
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